Abstract

ALONSO, Verónica Elsa López et al. Adrenalectomy and 5-HT_1A receptor: a microstructural analysis of feeding behavior. Acta comport. [online]. 2013, vol.21, n.4, pp.413-424. ISSN 0188-8145.

The objective of this research was to evaluate the effect of 5HT1A receptor stimulation of the hypothalamic paraventricular nucleus (PVN) on food intake and microstructural analysis in adrenalectomized rats. Four groups of rats (n = 10) were used, guide cannula was implanted into the PVN and adrenalectomy (ADX) was performed into three groups, a fourth group underwent a sham surgery (Sham group). The experimental subjects (rats) were assigned to one of four treatments: to Sham group saline was given, to group ADX saline was applied, the group 8-OH-DPAT was provided with 8-OH-DPAT (5-HT_1A agonist) and the pretreated group received 5-HT_1A antagonist WAY100635 + 8-OHDPAT. The results showed a significant decrease in the intake of carbohydrates and fat in the 8-OH-DPAT and pretreated groups. The hypophagic effect was not dependent on the interaction with 5-HT_1A receptors. Additionally behavioral analysis suggested that the hypophagic effect was due to early development of satiation process and the prolongation of a state of satiety.

Keywords : Feeding behavior; serotonin; hypothalamic paraventricular nucleus; 5-HT_1A receptors; microstructural analysis.

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