Resumo

IVANECKY, Igor  e  BELIK, Jaques. The contribution of arterial versus venous vascular permeability in peritoneal fluid formation. Rev. bras. crescimento desenvolv. hum. [online]. 2010, vol.20, n.3, pp. 762-768. ISSN 0104-1282.

OBJECTIVES: peritoneal fluid accumulation is a common finding in many children with abdominal disorders and its generation secondary to increased vascular permeability. The contribution of the arterial versus venous circulation to edema formation and peritoneal fluid accumulation is poorly understood. Studies conducted in vivo more than two decades ago suggested that the postcapillary venules were more important than the arterial vessels in the process of edema formation. The purpose of the present study as to evaluate the effect of changes in intravascular pressure and the inflammatory mediator bradykinin on rat mesenteric arterial and venous vascular permeability. METHOD: mesenteric arteries (MA) and veins (MV) were mounted on glass cannulas, intravascularly filled with fluorescent dextran and incrementally pressurized above their in vivo physiological values. Vascular permeability to dextran was determined at 100, 200 and 300 % of physiological pressures. RESULT: vascular permeability was present at all measurements for both vessels and its magnitude directly proportional to the intravascular pressure. Bradykinin (10^-5 M) significantly increased permeability in the MV but not in the MA. CONCLUSION: the abdominal fluid accumulation related to bowel inflammatory disease is more likely to be secondary to venous, as opposed to arterial vascular leakage.

Palavras-chave : capillary permeability; muscle smooth; vascular endothelium; vascular; Bradykinin; Cardiovascular System.

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