Resumo

GALESI, Fernanda Libardi; SILVA, Maria Teresa de Araújo  e  MIJARES, Miriam Garcia. Behavior analysis of the cue-induced animal model of drug relapse. Acta comport. [online]. 2012, vol.20, n.3, pp. 269-285. ISSN 0188-8145.

The purpose of this study was to analyze the stimulus control established by the animal model of drug relapse "cue-induced". Two groups of rats, ET and SAC, were exposed to a discrimination procedure. Lever press responses in the presence of orange odor (S^D1) were followed by a light stimulus (S^r1) and ethanol or sucrose release (ET or SAC groups, respectively), while responses in the presence of anise odor (S^D2) were followed by a sonorous stimulus (S^r2) and water release. Next, rats were placed on extinction conditions during which ethanol, sucrose and water, as well as the corresponding stimuli, were withdrawn. After extinction, S^Ds and S^rs were reintroduced, but lever press responses were not followed by ethanol, sucrose or water. In the first two sessions S^D1 and S^r1 or S^D2 and S^r2 were presented. In the remaining sessions, each stimulus was presented alone. This procedure was performed three times in order to control any effect of the order of stimuli presentation. The results showed that S^r1 presentation, alone or in the same session than S^D1, was effective in reinstating lever pressure responses for both groups. The results suggest that the cue-induced procedure may not be the most suitable one to study discriminative control over drug self-administration.

Palavras-chave : cue-induced; animal model; stimulus control; relapse; addiction.

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