Resumo

BIO, Danielle Soares; SOUZA, Érika Leonardo de  e  MORENO, Ricardo Alberto. Symptomatic remission and quality of life in patients with major depression treated with antidepressants: a prospective study. Aletheia [online]. 2011, n.34, pp. 151-162. ISSN 1413-0394.

This study aimed to estimate the QoL in individuals with severe Mood Depressive Disorder, before and after effective antidepressant treatment. The Sample consisted of 26 participants with MDD. Duration of study was 2 months. Symptoms were measured with the Montgomer-Asberg depression evaluations scale (MADRS) and the Hamilton Depression Scale (HAMD-17). QoL was measured using the Quality of Life and Satisfaction (Q-LES-Q). Treatment yielded significant improvement of depressive symptoms (HAM-D17: p<0.001 and MADRS: p< 0.001) and of quality of life (Q-LES-Q - p<0.001). As measured by the correlation coefficient, qualify of life and symptom scales were significantly correlated. At baseline, quality of life was positively correlated with MADRS (p=0.037), but not with HAMD (p=0.878). For all other time points, quality of life was positively correlated with MDRS and HAMD (p≤ 0.001); increased scores in the Q-LES-Q corresponded to decreased scores in the MADRS and HAMD scales. Symptomatic improvement is significantly correlated with improved QoL in individuals with MDD.

Palavras-chave : Major depressive disorder; Quality of life; Functional recovery; Antidepressant treatment.