Abstract

SILVA, Camila Lopes da; SANTOS, Maria Carolina Begliomini  and  HOSHINO, Katsumasa. Catalepsia induzida pelo lactato e atividade muscular forçada em ratos privados de sono. Rev. etol. [online]. 2010, vol.9, n.1, pp. 7-15. ISSN 1517-2805.

Catalepsy induced by lactate administration and forced muscular activity in rats. Comparative studies of behavioral homologies help understand several aspects of psychiatric disorders. The present study evaluated the effect of REM-sleep deprivation on the catalepsy induced by lactate administration plus forced muscular activity. Rats deprived of REM-sleep for 96 hs were injected i.p. with lactate solution 10mM/kg and submitted to 5 minutes of forced muscular activity. Catalepsy was then evaluated. The number of animals displaying catalepsy (50%) and mean total catalepsy time (11,92 ± 4,12 minutes) were lower in sleep deprived animals than in controls (91.7% and 26.67 ± 5.86 min respectively), results being statistically significant at the limit level (p=0,05). It is concluded that in long lasting dangerous situations, catalepsy may be triggered after normal wakefulness coping possibilities are exhausted, and sleep being manifested only when the risk situation is over.

Keywords : Catalepsy; Defensive behavior; Sleep; Rats.

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