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Cadernos de Pós-Graduação em Distúrbios do Desenvolvimento

Print version ISSN 1519-0307On-line version ISSN 1809-4139


RODRIGUES, Paula da Silva  and  BERNARDI, Maria Martha. Pre-clinical study of a sedative nutraceutic based on phytonutrients, ProSleepTM, in male mice: comparison with zolpidem. Cad. Pós-Grad. Distúrb. Desenvolv. [online]. 2020, vol.20, n.1, pp. 192-204. ISSN 1519-0307.

This study aimed to compare the sedative effect of a nutraceutical based on phytonutrients, ProSleepTM, in male mice with those of zolpidem, a hypnotic drug used as a sleep inducer. For this purpose, three tests were carried out to compare the effects of the two products: 1. the latency and duration of anesthesia induced by ketamine and xylazine, 2. sedation observed in the open field and 3. anxiety observed in an elevated plus-maze. The results showed that: 1. in the induction and duration of anesthesia the comparison between zolpiden and ProSleepTM: showed no significant differences; 2. in the open field, zolpiden and ProSleepTM similarly reduced the frequencies of total and peripheral locomotion and increased immobility when compared to the control group; 3. in the elevated plus-maze, no significant differences were observed after treatment when compared to the control group in all observed parameters. Both zolpiden and ProSleepTM improved the induction and duration of anesthesia and induced sedation in the open field. In addition, both zolpiden and ProSleepTM showed no anxiolytic effects. Thus, it can be suggested that ProSleepTM has the same pharmacological profile as zolpidem.

Keywords : Sleep inducer; Ketamine; Xylazine; Sedation; Zolpidem; Nutraceutical.

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