Resumo

RODRIGUES, Paula da Silva  e  BERNARDI, Maria Martha. Pre-clinical study of a sedative nutraceutic based on phytonutrients, ProSleep^TM, in male mice: comparison with zolpidem. Cad. Pós-Grad. Distúrb. Desenvolv. [online]. 2020, vol.20, n.1, pp. 192-204. ISSN 1519-0307.  http://dx.doi.org/10.5935/cadernosdisturbios.v20n1p192-204.

This study aimed to compare the sedative effect of a nutraceutical based on phytonutrients, ProSleep^TM, in male mice with those of zolpidem, a hypnotic drug used as a sleep inducer. For this purpose, three tests were carried out to compare the effects of the two products: 1. the latency and duration of anesthesia induced by ketamine and xylazine, 2. sedation observed in the open field and 3. anxiety observed in an elevated plus-maze. The results showed that: 1. in the induction and duration of anesthesia the comparison between zolpiden and ProSleep^TM: showed no significant differences; 2. in the open field, zolpiden and ProSleep^TM similarly reduced the frequencies of total and peripheral locomotion and increased immobility when compared to the control group; 3. in the elevated plus-maze, no significant differences were observed after treatment when compared to the control group in all observed parameters. Both zolpiden and ProSleep^TM improved the induction and duration of anesthesia and induced sedation in the open field. In addition, both zolpiden and ProSleep^TM showed no anxiolytic effects. Thus, it can be suggested that ProSleep^TM has the same pharmacological profile as zolpidem.

Palavras-chave : Sleep inducer; Ketamine; Xylazine; Sedation; Zolpidem; Nutraceutical.

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