Abstract

BILLMANN, Ariane; PEZZINI, Marina Ferri  and  POETA, Julia. Biomarkers in cerebrospinal fluid in development alzheimer's disease: a systematic review. Rev. Psicol. Saúde [online]. 2020, vol.12, n.2, pp. 141-153. ISSN 2177-093X.  http://dx.doi.org/10.20435/pssa.v0i0.927.

This study aimed to identify studies that analyzed the total tau (T-tau), phosphorylated tau (P-tau) and beta-amyloid (Aβ) biomarkers in the cerebrospinal fluid (CSF) to the development of Alzheimer's disease (AD). The study is characterized as a systematic review, that was applied a search logic in PubMed, SciELO e Medline, selecting studies according to inclusion and exclusion criteria. Eight clinical studies were evaluated, and all of these found elevated levels of T-tau and P-tau and decreased levels of Aβ, but not all studies found statistical significance in these findings. The dosage of the biomarkers Aβ, T-tau, and P-tau together present a great diagnostic potential of AD; however, more studies are needed to establish cutoff values of these biomarkers in disease progression.

Keywords : Alzheimer's; biomarkers; cerebrospinal fluid; tau; amyloid.

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