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Locus:1p13.2; OMIM: 605411; Gene: KCND3, Kv4.3; Ion channel and effect: ↑Ito ↑GOF for the phase-1 repolarization of the action potential; Protein: Potassium voltage-gated channel subfamily D member 3. Kv4.3, α-subunit of the transient outward potassium channel Ito. An increased Ito may directly affect cardiac conduction. However, the effects of an increased Ito on AP upstroke velocity or sodium current at the cellular level remain unknown.