Introduction:

diabetes mellitus significantly contributes to chronic ulcers, with over 30% of diabetics over 40 affected by lower limb ulcers, which can lead to severe complications if untreated. The Progressive Platelet Rich Fibrin (PRO-PRF) tissue regeneration matrix can be a technique to improve the dimensions of the membrane, its strength and cell distribution, aiding in the treatment of tissue reconstruction.

Objective:

to describe a series of cases of diabetic ulcers treated with autologous tissue regeneration matrix (PRO-PRF).

Methods:

a prospective, interventional case series study using a new tissue regeneration matrix protocol for the treatment of diabetic ulcers. This is an autologous matrix obtained by collecting peripheral blood and centrifuging it in a protocol of progressively increasing speeds.

Results:

29 patients were evaluated with a mean age of 60.54±9.75 years. 82.8% of the sample was male with an average body mass index (BMI) of 29.29±8.04Kg/m2 . Most of the lesions (41.4%) were located on the hallux. The median number of days of treatment was 14 (25% percentile of 7 and 75% percentile of 63 days). Statistical analysis showed a significant reduction in the size of the ulcers after treatment with PRO-PRF.

Conclusion:

the use of PRO-PRF proved to be an easy-to-use, low-cost and effective therapeutic option for treating chronic skin wounds on diabetic feet.