Resumo

VARELLA, Marco Antonio Correa et al. Determination of Twin Zygosity in Brazil: A DNA Validation of Two Short Questionnaires. Estud. psicol. (Natal) [online]. 2023, vol.28, n.1, pp.1-12.  Epub 23-Set-2023. ISSN 1413-294X.  https://doi.org/10.22491/1678-4669.20230001.

Twin research in Brazil is expanding and should be built upon solid foundations; this includes the use of zygosity questionnaires validated through DNA. Our goals were to adapt and validate two short zygosity questionnaires to Brazilian Portuguese using DNA testing of Brazilian twins. One hundred same-sex twin pairs (27 males and 73 females; 30.9±12.9 years) answered socio-demographic and two short zygosity questionnaires. Blood samples were collected for DNA extraction. A genetic analysis of 22 autosomic short tandem repeat plus amelogenin and DYS391 markers were conducted to obtain an individual genetic profile. According to DNA tests, 17% of twin pairs were classified as dizygotic and 83% as monozygotic. Both questionnaires correctly distinguished zygosity with 96.7% accuracy. These DNA validated zygosity questionnaires may foster twin research in Brazil, given the stronger methodology.

Palavras-chave : monozygotic twin; dizygotic twins; zygosity; questionnaire validation.

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